Titel och upphov Basic research and clinical aspects of adamantinomatous craniopharyngioma
Utgivning, distribution etc. Cham, Switzerland : Springer, 2017.
National Library of Medicine (NLM) klassifikationskod
DDC klassifikationskod (Dewey Decimal Classification)
Fysisk beskrivning 1 online resource (xii, 220 pages) : illustrations (some color)
Anmärkning: Allmän
Anmärkning: Bibliografi etc. Includes bibliographical references and index.
Anmärkning: Innehåll Pathogenesis of human ACP -- Transcriptomic and Genomic Analyses of Human Craniopharyngioma -- Genetically Modified Mouse Models of Adamantinomatous Craniopharyngioma -- Clinical Diagnosis of Human ACP -- Endocrine Deficits in Patients with Human Craniopharyngioma -- Obesity and metabolic disturbances in Adamantinomatous Craniopharyngioma Patients -- Radiology and Radiotherapy of Craniopharyngioma -- Surgical Treatment of Human ACP -- Intracystic Administration of Interferon-Alpha for Reduction of Cystic Tumour Burden -- Long-term Management and Clinical Trials in Adamantinomatous Craniopharyngioma.
Anmärkning: Innehållsbeskrivning, sammanfattning This astute volume brings together the latest expert research on adamantinomatous craniopharyngiomas (ACPs). ACPs are histologically benign but clinically aggressive tumors exhibiting a high propensity for local invasion into the hypothalamus, optic and vascular structures. These tumors, as well as the current treatments, may result in pan-hypopituitarism, diabetes insipidus, morbid obesity followed by type II diabetes mellitus, blindness, as well as serious behavioral and psychosocial impairments. Exploring in detail advances in both the understanding of tumor biology as well as clinical advances in patient management are explored in detail, this book will also look towards potential new treatment approaches. Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma is the first book compiling all current research on ACPs. Mouse and human studies have unequivocally demonstrated that mutations in CTNNB1 encoding -catenin underlie the etiology of the majority, if not all ACP tumors. Genetic studies in mice have shown that ACPs are tumors of the pituitary gland and not of the hypothalamus as previously thought, and are derived from Rathke's pouch precursors. In addition, a role for tissue-specific adult pituitary stem cells has been revealed as causative of ACP. Together, these studies have provided novel insights into the molecular and cellular etiology as well as the pathogenesis of human ACP. Finally, this volume covers new treatment approaches that have been shown to be effective both in reducing ACP burden as well as reducing the morbidity associated with therapy.
Term
Genre/Form
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Annat medium Print version: Basic research and clinical aspects of adamantinomatous craniopharyngioma. Cham, Switzerland : Springer, 2017 ISBN 3319518887 ISBN 9783319518886
Elektronisk adress och åtkomst (URI) http://link.springer.com/10.1007/978-3-319-51890-9
ISBN
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*24500$aBasic research and clinical aspects of adamantinomatous craniopharyngioma /$cJuan Pedro Martinez-Barbera, Cynthia Lilian Andoniadou, editors.
*264 1$aCham, Switzerland :$bSpringer,$c2017.
*300 $a1 online resource (xii, 220 pages) :$billustrations (some color)
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*500 $aIncludes index.
*504 $aIncludes bibliographical references and index.
*5050 $6880-01$aPathogenesis of human ACP -- Transcriptomic and Genomic Analyses of Human Craniopharyngioma -- Genetically Modified Mouse Models of Adamantinomatous Craniopharyngioma -- Clinical Diagnosis of Human ACP -- Endocrine Deficits in Patients with Human Craniopharyngioma -- Obesity and metabolic disturbances in Adamantinomatous Craniopharyngioma Patients -- Radiology and Radiotherapy of Craniopharyngioma -- Surgical Treatment of Human ACP -- Intracystic Administration of Interferon-Alpha for Reduction of Cystic Tumour Burden -- Long-term Management and Clinical Trials in Adamantinomatous Craniopharyngioma.
*520 $aThis astute volume brings together the latest expert research on adamantinomatous craniopharyngiomas (ACPs). ACPs are histologically benign but clinically aggressive tumors exhibiting a high propensity for local invasion into the hypothalamus, optic and vascular structures. These tumors, as well as the current treatments, may result in pan-hypopituitarism, diabetes insipidus, morbid obesity followed by type II diabetes mellitus, blindness, as well as serious behavioral and psychosocial impairments. Exploring in detail advances in both the understanding of tumor biology as well as clinical advances in patient management are explored in detail, this book will also look towards potential new treatment approaches. Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma is the first book compiling all current research on ACPs. Mouse and human studies have unequivocally demonstrated that mutations in CTNNB1 encoding -catenin underlie the etiology of the majority, if not all ACP tumors. Genetic studies in mice have shown that ACPs are tumors of the pituitary gland and not of the hypothalamus as previously thought, and are derived from Rathke's pouch precursors. In addition, a role for tissue-specific adult pituitary stem cells has been revealed as causative of ACP. Together, these studies have provided novel insights into the molecular and cellular etiology as well as the pathogenesis of human ACP. Finally, this volume covers new treatment approaches that have been shown to be effective both in reducing ACP burden as well as reducing the morbidity associated with therapy.
*5880 $aOnline resource; title from PDF title page (SpringerLink, viewed April 27, 2017).
*590 $aSpringerLink$bSpringer Medicine eBooks 2017 English+International
*650 0$aBrain$xTumors.
*650 0$aSkull$xTumors.
*650 0$aCancer in children.
*650 7$aMEDICAL$xGynecology & Obstetrics.$2bisacsh
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*650 2$aBrain Neoplasms.
*655 4$aElectronic books.
*7001 $aMartinez-Barbera, Juan Pedro,$eeditor.
*7001 $aAndoniadou, Cynthia Lilian,$eeditor.
*77608$iPrint version:$tBasic research and clinical aspects of adamantinomatous craniopharyngioma.$dCham, Switzerland : Springer, 2017$z3319518887$z9783319518886$wIMP(OCoLC)(OCoLC)965339537
*85640$uhttp://link.springer.com/10.1007/978-3-319-51890-9
*8808 $6505-00/(S$aImpact of Activated Signalling Pathways on Proliferation and Differentiation in ACPs Occurrence of Tumour Stem Cells in ACP; Wnt and EGFR Pathways were Identified as Being Involved in the Cellular Motility of ACP; References; Transcriptomic and Genomic Analyses of Human Craniopharyngioma; Introduction; Adamantinomatous Craniopharyngioma; β-Catenin and the WNT/Wingless Pathway; ACP Genome Analyses; CTNNB1 Mutation; Epidermal Growth Factor Receptor; SHH; Additional Potential Relevant Pathways; Papillary Craniopharyngioma; Distinction from ACP; BRAF; Summary; References.
*8800 $6505-00/(S$aPreface; Contents; About the Editors; Contributors; Pathogenesis of Human ACP; Definition and Historical Notes; Variants; Epidemiology; Morphological and Histological Characteristics of CP Subtypes; Genetic Distinctions of CP Subtypes; β-catenin: A Multifunctional Protein and Key Component of the Canonical Wnt Signalling Pathway; Mutations in exon 3 (CTNNB1) are not Sufficient to Induce Nuclear β-Catenin Accumulation in ACP Per se; ACPs Show Activation of Wnt Signalling Target Genes in Cell Clusters with Nuclear β-Catenin Accumulation; Axin2; BMP4; Fascin; Activated EGFR; SHH.
*8808 $6505-01/(S$aGenetically Modified Mouse Models of Adamantinomatous Craniopharyngioma Normal Development of the Pituitary Gland; Pathology of Human ACP; Over-Activation of the WNT/β-Catenin Pathway Underlies the Molecular Aetiology of Human and Mouse ACP; Childhood-Onset ACP is Likely to be a Tumour of Embryonic Origin; Pituitary Stem Cells are Present in Mouse and Human Pituitaries; Contribution of Stem Cells in the Long-Term Maintenance of the Anterior Pituitary; Paracrine Contribution of Stem Cells to Tumourigenesis; Conclusions; References; Clinical Diagnosis of Human ACP; Introduction.
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*938 $aYBP Library Services$bYANK$n14255982
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